They went from being married to being friends with benefits, with Cristina commenting to Meredith that having sex with someone who used to be your husband is way better than when you're still married. After they got a call from their lawyers, they went to the courtroom to find out they won the case and were awarded with 15 million dollars each. When they returned to the hospital, Cristina revealed to Derek that she figured out Meredith was pregnant, even though Meredith hadn't told her yet. She and Owen went to an on-call room where they talked about the plane crash lawsuit. She asked him to come to Callie's survivor dinner that night, but he refused as Derek was still blaming him. Cristina wanted to comment on this, but he told her he just wanted to enjoy the moment of them being together and they started to undress. After the sex, Cristina went to talk to Derek and begged him to forgive Owen so they could all move past the plane crash, but Derek said it wasn't that easy.
Although she pretended to not care, Cristina was hurt by his decision and decided against telling Burke about her pregnancy. However while in surgery with Burke, she collapsed from an ectopic pregnancy and her left fallopian tube burst.[42] Burke was shocked to find out about the pregnancy, but Cristina reminded him that he broke up with her. Despite that, he was the only one whom she allowed to comfort her when she could not stop crying from her grief.
Cristina's life was further complicated when her former professor and lover, Colin Marlow, arrived at Seattle Grace. In a bid to win her back, he repeatedly came onto her and tried to sabotage her relationship with Burke. On top of that, he joined the race for Chief of Surgery, so as to compete with Burke and impress her. Cristina resorted to acting extremely affectionate with Burke, after direct attempts at getting Marlow to leave Seattle Grace failed. However, Marlow was not convinced by this and used the opportunity of a rare surgery to lure Cristina to his side.
He told her that he was married. She told him to kiss her anyway, which he did. One thing led to another and they had sex. Deciding on Fellowship Programs
Cristina then told Meredith she would be there and hearing that Meredith would suffer more than her, as she'd know Cristina saw her poop on the table, made her feel a little bit better. She walked into Owen and she told him she was sorry about Paul's wife. He barely reacted and she asked if he was angry with her, but he was just angry at encontre mais the situation. Cristina suggested they go home to relax a little, but he wanted to stay in case Paul's condition would change or Ethan would need something. He just didn't feel like he could leave and asked her what she would do. She replied she would go home because she was his doctor, not his family. He still decided to stay and she told him she understood. At the end of the day, Cristina had a meeting where Bailey was found to have spread an infection due to microtears in the gloves, which were implemented by Pegasus' protocol. The blame was all on the gloves and Bailey could return to the OR once she was infection-free, which was the best outcome, Cristina told her. That night, Alex came to talk to her and he confessed indeed loving Jo. On her turn, she confessed that she thought she was losing Owen, not today, but soon.[28]
Ezio, who was not used to being turned down by a woman, shadowed Cristina from the rooftops and eventually followed her to her home, where he saw her being confronted by Vieri do' Pazzi.[2]
While looking at her patient's scans with Owen, there was some romantic tension and he told her he would normally kiss her. Callie interrupted the moment by coming in to ask questions about couples therapy, but offended them both by saying couple's therapy obviously hadn't done them any good. At the end of the day, Cristina and Owen ended up in the elevator together. She told him they would eventually be drawn together again, and then proposed they both date other people. She admitted it would feel forced, but it might help them to get over each other and she made him promise to at least try it.[34]
 Cristina immediately realized that Derek's life was in danger, but once she divulged that Derek was one of the intended targets Meredith couldn't stand staying in place. Cristina tried to bodily stop her, but Meredith shoved her aside and ran out into the hallway.
Probably two of each, she pointed out and fakely apologized. This only left him with her, determined to take over the work of those four people and do her very best at it. She would treat his patients, take his surgeries and assist in research, including projects she'd find on her own. "Pile it on," she said and he started objecting he couldn't do that, but she told him the board believed he could. In the evening, she took a whole bunch of research material home with her to get through that night.[25] Breaking Up with Owen
Cristina said that she couldn't just turn off her brain therein indicating she was becoming frustrated with the lack of intellectual stimulus in her new unemployed existence. Eventually, she did catch a fish, a 28 pounder, Cristina got her picture taken with it but suddenly she started crying. It seemed that finally, Cristina was ready to begin healing. Having an Abortion
Owen moved out of the firehouse and Cristina started to plan to move to Minnesota and accept the fellowship offer at Mayo Clinic. However, before leaving, she slept with Owen one last time, forgiving his infidelity.
Rest in peace, Christina Grimmie. We love and miss you so much . Thank you for everything you've done. Heaven really did gain another angel and I know you'll be looking down at us from above.
After the crash, Cristina's shoulder was dislocated and she somehow lost one of her shoes. She helped a confused Meredith get back up and told her that the plane crashed. Meredith also couldn't find Derek lying around anywhere, and Cristina remembered that he was sucked out the side when the plane hit the trees, and that the back of the plane came off.
She began looking down on Burke for beliefs she considered irrational, while Burke was hurt and angry she wouldn't accept his spirituality. This clash in belief caused tension between Cristina and Burke, but it was subsequently resolved.